Interstate 40 traverses Needles east to west, with Highway 95 (the Trans-National Highway from Mexico to Canada) providing north-south access. The Burlington Northern Santa Fe Railroad ("BNSF") has a hub at Needles. Amtrak provides two trains a day form Needles to Los Angeles, and Needles to Chicago. Greyhound Bus Lines provides twice daily stops at Needles. The Needles Area Transit ("NAT") bus that runs at conveniently scheduled intervals throughout Needles provides local bus service.

The Laughlin - Bullhead International Airport is approximately 25 miles from Needles, providing flights by Sun Country Airlines which is currently providing quality, affordable scheduled air service to the most popular destinations including Dallas, Ft. Myers, Las Vegas, Laughlin, Los Angeles, Minneapolis/St. Paul, Orlando, Phoenix, Portland, San Diego and San Francisco.